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Nr1h2 Gene Detail
Summary
  • Symbol
    Nr1h2
  • Name
    nuclear receptor subfamily 1, group H, member 2
  • Synonyms
    LXRB, LXRbeta, RIP15, Unr2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352463
    NCBI Gene: 22260
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44199040-44203375 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 28.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352463
 protein coding gene Chr7:44199040-44204928 (-)
129S1/SvImJ ENSMUSG00200024550
 protein coding gene Chr7:31791576-31795172 (-)
A/J ENSMUSG00195046849
 protein coding gene Chr7:35819681-35823277 (-)
AKR/J ENSMUSG00220007453
 protein coding gene Chr7:30124507-30128103 (-)
BALB/cJ ENSMUSG00180035244
 protein coding gene Chr7:32695067-32698663 (-)
C3H/HeJ ENSMUSG00175034731
 protein coding gene Chr7:33227526-33231122 (-)
C57BL/6NJ ENSMUSG00215043288
 protein coding gene Chr7:32488793-32492389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029666
 protein coding gene Chr7:46491692-46496043 (-)
CAST/EiJ ENSTCUG00005045899
 protein coding gene Chr7:36205307-36208903 (-)
CBA/J ENSMUSG00210047010
 protein coding gene Chr7:33598905-33602501 (-)
DBA/2J ENSMUSG00185042527
 protein coding gene Chr7:37464376-37467976 (-)
FVB/NJ ENSMUSG00205034776
 protein coding gene Chr7:33144096-33147692 (-)
JF1/MsJ ENSUMUG00000014166
 protein coding gene Chr7:41951586-41955186 (-)
LP/J ENSMUSG00230050167
 protein coding gene Chr7:42894494-42898090 (-)
NOD/ShiLtJ ENSMUSG00190025030
 protein coding gene Chr7:33471889-33475485 (-)
NZO/HlLtJ ENSMUSG00225016066
 protein coding gene Chr7:41105282-41108878 (-)
PWK/PhJ ENSLUMG00010037831
 protein coding gene Chr7:32427652-32431252 (-)
SPRET/EiJ ENSMSPG00010037337
 protein coding gene Chr7:32209377-32213706 (-)
WSB/EiJ ENSIUOG00005023908
 protein coding gene Chr7:34017015-34020611 (-)



Homology
more
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NR1H2, nuclear receptor subfamily 1 group H member 2
  • Synonyms
    LXR-b, LXRB, NER, NER-I, RIP15, UNR
  • Links
    NCBI Gene ID: 7376
    UniProt: P55055

  • Chr Location
    19q13.33; chr19:50329640-50383404 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human NR1H2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    33 phenotypes from 5 alleles in 6 genetic backgrounds
    62 phenotypes from multigenic genotypes
    175 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutations cause altered lipid, cholesterol and glucose metabolism and may lead to elevated cartilage matrix catabolism and PGE2 production, lipid-laden uterus myocytes and Sertoli cells, impaired uterus contractility and parturition, and higher susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    90
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    685
  • Tissues
    73
  • cDNA Data
    137
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000060601 Ensembl Gene Model | MGI Sequence Detail 4336 C57BL/6J ±  kb
    transcript ENSMUST00000167197 Ensembl | MGI Sequence Detail 1944 Not Applicable  
    polypeptide ENSMUSP00000126788 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 140
      cDNA 138
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-24047, MGI:103179, MGI:2141876
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 17
      Diseases 2
      Gene Ontology 21
      Phenotypes 175
    • Earliest
      J:23077 Seol W, et al., Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors. Mol Endocrinol. 1995 Jan;9(1):72-85
    • Latest
      J:372862 Lv K, et al., Inactivation of microglial LXRbeta in early postnatal mice impairs microglia homeostasis and causes long-lasting cognitive dysfunction. Proc Natl Acad Sci U S A. 2025 Apr 15;122(15):e2410698122
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory